Synthesis of 1, 2??Disubstituted Benzimidazoles by a Cu??Catalyzed Cascade Aryl Amination/Condensation Process

B Zou, Q Yuan, D Ma

Index: Zou, Benli; Yuan, Qiliang; Ma, Dawei Angewandte Chemie - International Edition, 2007 , vol. 46, # 15 p. 2598 - 2601

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Citation Number: 287

Abstract

1, 2-Disubstituted benzimidazoles are an important class of heterocyclic compounds that exhibit a wide range of biological properties.[1] Previous syntheses of 1, 2-disubstituted benzimidazole structures not only led to drug leads such as the hepatitis C virus (HCV) NS5B polymerase inhibitor 1 [2] and the agonist 2 against the g-aminobutyric acid A receptor (GABAA),[3] but also resulted in commercial pharmaceutical products such as the ...