Organosilicon Compounds as Adult T-Cell Leukemia Cell Proliferation Inhibitors

M Nakamura, Y Matsumoto, M Toyama…

Index: Nakamura, Masaharu; Matsumoto, Yotaro; Toyama, Masaaki; Baba, Masanori; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 2 p. 237 - 241

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Citation Number: 2

Abstract

Aggressive forms of adult T-cell leukemia (ATL) respond poorly to conventional anticancer chemotherapy, and new lead compounds are required for the development of drugs to treat this fatal disease. Recently, we developed ATL cell-selective proliferation inhibitors based on a tetrahydrotetramethylnaphthalene (TMN) skeleton 1, and here we report the design and synthesis of silicon analogs of TMN derivatives. Among them, compound 13 showed the ...