Ring-substituted [1, 2-bis (4-hydroxyphenyl) ethylenediamine] dichloroplatinum (II) complexes: compounds with a selective effect on the hormone-dependent …

J Karl, R Gust, T Spruss, MR Schneider…

Index: Karl, Johann; Gust, Ronald; Spruss, Thilo; Schneider, Martin R.; Schoenenberg, Helmut; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 72 - 83

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Citation Number: 86

Abstract

(CH3, CFs, F, C1, Br, I: meso-and d, ll-PtClz, meso-(3-5)-PtC12, meso-(7 and 8)-PtCl,) or two substituents in the 2, 6-positions (CH3, Ck meso-%-PtC12, meso-and d, l-6-PtClZ) in both benzene rings were synthesized and tested for estrogenic and cytotoxic activities. Two complexes (meso-6-PtC1, and meso-7-PtClz) possess both effects. In comparative tests on estrogen receptor positive and negative mammary tumors in cell culture (MCF 7, ER" and ...