Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels

S Patil, AN Bukiya, W Li, AM Dopico, D Miller

Index: Patil, Shivaputra; Bukiya, Anna N.; Li, Wei; Dopico, Alejandro M.; Miller, Duane Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3427 - 3430

Full Text: HTML

Citation Number: 5

Abstract

Physiological and pharmacological agents that activate large conductance, voltage-, and calcium-gated potassium (BK) channels located in the smooth muscle are effective vasodilators. Thus, activators of smooth muscle BK channels may be potential therapeutic tools to treat cardiovascular disease associated with vasoconstriction and/or impaired dilation, such as cerebrovascular spasm and constriction. We previously showed that ...