Kilogram Synthesis of a Second-Generation LFA-1/ICAM Inhibitor
AJ DelMonte, Y Fan, KP Girard, GS Jones…
Index: Zhang, Huiping; Watterson, Scott H.; Xiao, Zili; Dhar, T. G. Murali; Balasubramanian, Balu; Barrish, Joel C.; Chen, Bang-Chi Organic Process Research and Development, 2010 , vol. 14, # 4 p. 936 - 938
Full Text: HTML
Citation Number: 4
Abstract
... mL/g of 1 M NaOH solution to remove the 0.5 equiv of the DTTA.(12) Following a 5 mL/g aqueous wash, the organic layer was ... 5a from 4b. Addition of solid tert-butyl nicotinic ester 3 to 4a with 2.5 equiv of DIPEA and heating the reaction at 112 °C for 18 h in dimethylacetamide ...
Related Articles:
[Journal of Medicinal Chemistry, , vol. 29, # 5 p. 860 - 862]
Recent Developments in Oxidative Processes in Steroid Chemistry
[Kovganko; Chernov; Sokolov; Kashkan; Survilo Chemistry of Natural Compounds, 2009 , vol. 45, # 2 p. 200 - 204]
[Heteroatom Chemistry, , vol. 15, # 1 p. 67 - 70]
Site-selectivity in the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride.
[Chemical and Pharmaceutical Bulletin, , vol. 36, p. 2244 - 2247]
[Journal of Materials Chemistry, , vol. 15, # 48 p. 5164 - 5173]