Nucleotides. Part XXVII Bis [2??(p??nitrophenyl) ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry

F Himmelsbach, R Charubala…

Index: Himmelsbach, Frank; Charubala, Ramamurthy; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1987 , vol. 70, p. 1286 - 1295

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Citation Number: 13

Abstract

Abstract A new, versatile phosphorylating agent, bis [2-(p-nitrophenyl) ethyl] phosphorochloridate (3), has been prepared and is used for 3′-and/or 5′- phosphorylations of nucleosides. The resulting bis [2-(p-nitrophenyl) ethyl] phosphotriesters are versatile synthons in oligonucleotide synthesis leading finally to 3′-and/or 5′- terminated monophosphates in excellent yields.