(Fluorocyclopropyl) quinolones. 2. Synthesis and Stereochemical Structure-Activity Relationships of Chiral 7-(7-Amino-5-azaspiro [2.4] heptan-5-yl)-1-(2- …

Y Kimura, S Atarashi, K Kawakami, K Sato…

Index: Kimura; Atarashi; Kawakami; Sato; Hayakawa Journal of Medicinal Chemistry, 1994 ,  vol. 37,  # 20  p. 3344 - 3352

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Citation Number: 82

Abstract

quinolones were synthesized as a continuation of a research project of 1-(2- fluorocyclopropyl)-quinolones by considering stereochemical and physicochemical properties of the molecule. Absolute configurations of the l-(cis-2-fluorocyclopropyl) moiety and the 747-amin0-5-azaspiro-[2.4] heptan-5-yl) moiety were determined by X-ray crystallographic analysis. Stereochemical structure-activity relationship studies indicated ...