Synthesis of costatolide, a halogenated monoterpenoid from the red alga Plocamium costatum

PG Williard, LA Grab, SE De Laszlo

Index: Williard, Paul G.; Grab, Lawrence A.; Laszlo, Stephen E. de Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1123 - 1125

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Citation Number: 13

Abstract

N-Aminophthalimide (0.01 mol) was stirred with dry dichloromethane (15 mL/g), and the olefin (0.011 mol) was added. Lead tetraacetate (0.012 mol) was then added to the stirred suspension at 5-10" C during 10 min. After being stirred for a further 15 min, the reaction mixture was fitered, and the residue was washed with dichloromethane. The combined filtrate was then washed sequentially with water and with a saturated solution of sodium ...