Synthesis of the lipid peroxidation product 4??hydroxy??2 (E)??nonenal with 13C stable isotope incorporation

…, V Sreevani, E Rathahao, F Gueraud…

Index: Jouanin; Sreevani; Rathahao; Gueraud; Paris Journal of Labelled Compounds and Radiopharmaceuticals, 2008 ,  vol. 51,  # 2  p. 87 - 92

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Citation Number: 7

Abstract

Abstract The aim of this work was to synthesize 13 C internal standards for the quantification of 4-hydroxy-2 (E)-nonenal (HNE), a lipid peroxidation product, and of the etheno-adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight-step synthesis starting from ethyl 2-bromoacetate and giving access to 4-[(tetrahydro-2H-pyran-2-yl) oxy]-2 (E)-nonenal. This compound is a precursor of HNE. The scheme was then used to ...