Mechanistic studies on a placental aromatase model reaction

PA Cole, CH Robinson

Index: Cole, Philip A.; Robinson, Cecil H. Journal of the American Chemical Society, 1991 ,  vol. 113,  # 21  p. 8130 - 8137

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Citation Number: 57

Abstract

Abstract: Aromatase is a Cytochrome P-450 enzyme that converts androgens to estrogens via three successive oxidative reactions. The mechanism of the third step has previously been intensively studied, with no clear resolution. A leading theory for the third step proposes nucleophilic attack of the heme ferric peroxide species on the 19-aldehyde intermediate to produce a 19-hydroxy 19-ferric peroxide intermediate. We have shown ...