Synthesis and antitumor activity of N-terminal proline-containing peptide-(chloroethyl) nitrosoureas

H Suli-Vargha, A Jeney, K Lapis…

Index: Suli-Vargha; Jeney; Lapis; Medzihradszky Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 3  p. 583 - 586

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Citation Number: 13

Abstract

The N~-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of H-Pro-Lys (X)-Pro-Val-NH,(X: tert- butyloxycarbonyl, formyl,(2-chloroethyl) nitrosocarbamoyl) were synthesized. It was found that the bis-substitution of the urea N3 in these derivatives does not decrease the antitumor activity influenced mainly by the nature of the carrier molecule as a whole.