Process development and scale-up of AZD7545, a PDK inhibitor

B Patel, CR Firkin, EW Snape, SL Jenkin…

Index: Patel, Bharti; Firkin, Catherine R.; Snape, Evan W.; Jenkin, Shelley L.; Brown, David; Chaffey, Julian G. K.; Hopes, Philip A.; Reens, Carl D.; Butters, Mike; Moseley, Jonathan D. Organic Process Research and Development, 2012 ,  vol. 16,  # 3  p. 447 - 460

Full Text: HTML

Citation Number: 8

Abstract

A brief comparison of the early manufacturing routes to AZD7545 is given. Process development of the preferred long-term manufacturing route is reported in detail, and changes from the initial kilogram-scale route are discussed. Scale-up experience from the pilot-plant manufacture is included in the discussion of each stage. Noteworthy aspects throughout the development of AZD7545 concerned chemical hazards, mechanisms, ...