Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2

MP Clark, MW Ledeboer, I Davies…

Index: Pautus, Stephane; Sehr, Peter; Lewis, Joe; Fortune, Antoine; Wolkerstorfer, Andrea; Szolar, Oliver; Guilligay, Delphine; Lunardi, Thomas; Decout, Jean-Luc; Cusack, Stephen Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8915 - 8930

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Citation Number: 25

Abstract

... Journal of Medicinal Chemistry. ...

A model for interactions of amino acid side chains with Watson-Crick base pair of guanine and cytosine. Crystal structures of 9-(2-carboxyethyl) guanine and its …

[Fujita; Takenaka; Sasada Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 7 p. 1707 - 1712]

1H MAS, 15N CPMAS, and DFT investigation of hydrogen-bonded supramolecular adducts between the diamine 1, 4-diazabicyclo-[2.2. 2] octane and dicarboxylic …

[Tarui, Mariko; Nomoto, Noriko; Hasegawa, Yoko; Minoura, Katsuhiko; Doi, Mitsunobu; Ishida, Toshimasa Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 11 p. 1998 - 2002]

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2

Abstract

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