A new preparative method for the synthesis of diethyl 1-diazo-2, 2, 2-trifluoroethylphosphonate via an imino phosphonate

NM Karimova, DV Vorobyeva, GT Shchetnikov…

Index: Karimova; Vorobyeva; Shchetnikov; Osipov Russian Chemical Bulletin, 2010 ,  vol. 59,  # 1  p. 107 - 109

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Citation Number: 11

Abstract

Abstract A preparative method for the synthesis of diethyl 1-diazo-2, 2, 2- trifluoroethylphosphonate from trifluoroacetic anhydride and benzyl carbamate via diethyl 1- benzyloxycarbonylimino-2, 2, 2-trifluoroethylphosphonate is developed. Optimum conditions for the chlorination of benzyl N-trifluoroacetylcarbamate with SOCl 2—Py to afford the imidoyl chloride, phosphorylation of the latter under the conditions of the Arbuzov reaction, ...