The Gas-Solid-Phase 2, 5-Dioxopiperazine Synthesis. Cyclization of Vaporous Dipeptides on Silica Surface

VA Basiuk, TY Gromovoy

Index: Basiuk, Vladimir; Gromovoy, Taras Yu. Collection of Czechoslovak Chemical Communications, 1994 ,  vol. 59,  # 2  p. 461 - 466

Full Text: HTML

Citation Number: 13

Abstract

Recently we have reported on the “gas–solid-phase” synthesis of 2,5-dioxopiperazines (DOPs) via cyclodimerization of vaporous amino acids on silica surface1. The pre- requisite for realization of this method is the ability of amino acids to sublime in va- cuum without decomposition, intermolecular condensation and loss of optical activity2. Besides amino acids themselves, this property is characteristic also for some simple dipeptides, ie dipeptides ...