Journal of medicinal chemistry

Synthesis of 2, 4, 5-trihydroxyphenylalanine (6-hydroxydopa). A centrally active norepinephrine-depleting agent

HH Ong, CR Creveling, JW Daly

Index: Ong,H.H. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 458 - 461

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Citation Number: 46

Abstract

Biochemzstry, 4, 2513 (1965). malonate (III).---To a solution of 0.433 g (0.001 mole) of dibenzyl carbobenzyloxyaminomalonate in 8 ml of anhydrous Phlle was added 58 mg of a SaH slurry (535 in mineral oil, 0.0013 mole) under S2. The mixture was heated and stirred at 100" until the gas evolution had subsided (30 min). 2, 4, 5-Tribenzyloxybenzyl bromide (528 mg) mm added and the mixture was refluxed for an additional 18 hr. The chiiled mixture u' ...