Green, catalyst-free thioacetalization of carbonyl compounds using glycerol as recyclable solvent

G Perin, LG Mello, CS Radatz, L Savegnago, D Alves…

Index: Perin, Gelson; Mello, Luzia G.; Radatz, Catia S.; Savegnago, Lucielli; Alves, Diego; Jacob, Raquel G.; Lenardao, Eder J. Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4354 - 4356

Full Text: HTML

Citation Number: 42

Abstract

We describe herein the use of glycerol as an efficient and a recyclable solvent in the thioacetalization of aldehydes and ketones. The catalyst-free reactions proceed easily using glycerol at 90° C and the corresponding thioacetals were obtained in good to excellent yields. Glycerol was recovered and utilized for further thioacetalization reactions.