Bisoxazoline ligands with an axial-unfixed biaryl backbone: the effects of the biaryl backbone and the substituent at oxazoline ring on Cu-catalyzed asymmetric …

…, S Matsuo, Y Imahori, T Kida, Y Nakatsuji, I Ikeda

Index: Zhang, Wanbin; Xie, Fang; Matsuo, Shigeaki; Imahori, Yuji; Kida, Toshiyuki; Nakatsuji, Yohji; Ikeda, Isao Tetrahedron Asymmetry, 2006 , vol. 17, # 5 p. 767 - 777

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Citation Number: 26

Abstract

The synthesis of novel C2-symmetric bisoxazoline ligands with an axial-unfixed biaryl backbone and different substituents at the oxazoline ring is reported. The diastereomer equilibrium of these ligands in solution and their complexation behavior with the copper (I) ion were studied. Their application in Cu-catalyzed cyclopropanation of styrene, with diazoacetate, was carried out and the effects of the biaryl backbone and the substituent on ...