Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

…, EK Kim, MJ Park, SU Choi, CO Lee, SH Cheon…

Index: Cho, Won-Jea; Kim, Eui-Ki; Park, Myun-Ji; Choi, Sang-Un; Lee, Chong-Ock; Cheon, Seung Hoon; Choi, Bo-Gil; Chung, Byung-Ho Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2449 - 2458

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Citation Number: 23

Abstract

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure—activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. ...