Photochemical control of RNA structure by disrupting π-stacking

…, A Schön, E Freire, MM Greenberg

Index: Resendiz, Marino J. E.; Schoen, Arne; Freire, Ernesto; Greenberg, Marc M. Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12478 - 12481

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Citation Number: 10

Abstract

Photolabile nucleotides that disrupt nucleic acid structure are useful mechanistic probes and can be used as tools for regulating biochemical processes. Previous probes can be limited by the need to incorporate multiple modified nucleotides into oligonucleotides and in kinetic studies by the rate-limiting step in the conversion to the native nucleotide. Photolysis of aryl sulfide 1 produces high yields of 5-methyluridine, and product formation is complete in ...