Phytochemistry
The first prenylation step in hyperforin biosynthesis
Z Boubakir, T Beuerle, B Liu, L Beerhues
Index: Boubakir, Zakia; Beuerle, Till; Liu, Benye; Beerhues, Ludger Phytochemistry, 2005 , vol. 66, # 1 p. 51 - 57
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Citation Number: 35
Abstract
Prenylation reactions contribute considerably to the diversity of natural products. Polyprenylated secondary metabolites include hyperforin which is both quantitatively and pharmacologically a major constituent of the medicinal plant Hypericum perforatum (St. John's wort). Cell cultures of the related species Hypericum calycinum were found to contain a prenyltransferase activity which is likely to catalyze the first prenylation step in hyperforin ...