A Ruthenium??Catalyzed Approach to the Friedländer Quinoline Synthesis

…, P Van Der Voort, D De Vos, F Verpoort

Index: Mierde, Hans Vander; Van Der Voort, Pascal; De Vos, Dirk; Verpoort, Francis European Journal of Organic Chemistry, 2008 , # 9 p. 1625 - 1631

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Citation Number: 27

Abstract

Abstract In a modification of the Friedländer reaction, 2-aminobenzyl alcohol is oxidatively cyclized with a variety of ketones to yield substituted quinolines. Of all the ruthenium catalysts that were tested for this reaction, the second-generation Grubbs' catalyst gives the highest quinoline yield, in combination with KOtBu as a base. The presence of a hydrogen acceptor is required to regenerate the catalyst. Also the reaction mechanism is discussed, ...

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