N-Heterocyclic compounds as radioprotectors. 1. 2-Pyridinemethanethiol, 2-pyrazinemethanethiol and related compounds

…, GF Esslemont, CEL Jones, M Fatome

Index: Barnes; Fatome; Esslemont; Jones European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 515 - 519

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Citation Number: 9

Abstract

2-Pyridinemethanethiol 1, which is structurally related to cysteamine, showed good radioprotective potency in mice, but 2-pyrazine-methanethiol 9 was inactive. Certain derivatives of 1 and 9 that were synthesised were radioprotective. The 3 isomeric mercaptopyridines showed activity. Further study of N-heteroaromatic compounds as radioprotectors is indicated. An improved method for the preparation of 9 is described