Synthesis of some new thiazolidin-5-one derivatives of pharmaceutical interest

MA Metwally, EM Keshk, A Fekry…

Index: Metwally; Keshk; Fekry; Etman Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 10 p. 2067 - 2079

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Citation Number: 7

Abstract

Condensation of thiazolidin-5-one derivative 1 with different aromatic aldehydes gave the corresponding arylidenes 2a–e. Compound 2e was reacted with urea and thiourea to give the corresponding thiazolo [5, 4-d] pyrimidine derivatives 3a, b, respectively. Treatment of compound 1 with phenyl isothiocyanate in basic DMF gave the nonisolable potassium salt of the adduct 4, which underwent heterocyclization upon treatment with chloroacetyl chloride ...