Design and Development of the First Peptide??Chelating Bisphosphane Bioconjugate from a Novel Functionalized Phosphorus (III) Hydride Synthon

H Gali, SR Karra, VS Reddy…

Index: Gali, Hariprasad; Karra, Srinivasa R.; Reddy, V. Sreenivasa; Katti, Kattesh V. Angewandte Chemie - International Edition, 1999 , vol. 38, # 13-14 p. 2020 - 2023

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Citation Number: 33

Abstract

Abstract Remarkable oxidative stability is shown by the carboxylate-functionalized primary bisphosphane 1. Compound 1 can be used in conjugation reactions with biomolecules for functionalization through the COOH group without prior protection of PH 2 groups. A novel water-soluble bisphosphane was obtained by reaction of the PH 2 groups of 1 with formaldehyde under mild conditions.