The Journal of organic chemistry

Copper-catalyzed N-arylation of 2-imidazolines with aryl iodides

OA Davis, M Hughes, JA Bull

Index: Davis, Owen A.; Hughes, Matthew; Bull, James A. Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3470 - 3475

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Citation Number: 18

Abstract

The first copper-catalyzed N-arylation of 2-imidazolines is described. The reaction affords compounds with desirable lead-like characteristics in high yield with practical simplicity under inexpensive,“ligand-free” conditions. The cross coupling was successful with electron- rich and electron-poor aromatic iodides. Substrates bearing halides, esters, nitriles, and free hydroxyls are well tolerated, providing reactive handles for further functionalization, as are ...