Synthesis and biological evaluation of ABCD ring fragments of the kibdelones

DL Sloman, B Mitasev, SS Scully…

Index: Sloman, David L.; Mitasev, Branko; Scully, Stephen S.; Beutler, John A.; Porco Jr., John A. Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2511 - 2515

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Citation Number: 31

Abstract

The kibdelones A–C (1–3) and their isomeric metabolites (cf. isokibdelone C; 4) are hexacyclic tetrahydroxanthone natural products recently isolated by Capon and co-workers from the rare Australian actinomycete Kibdelosporangium sp.(Figure 1).[1] An interesting property is the facile equilibration of kibdelones B (2) and C (3) to a mixture of 1–3 through keto–enol tautomerizations followed by quinone–hydroquinone redox reactions.[1] ...