Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents

R Kollock, W Meinl, H Schneider, M Batke…

Index: Kollock, Ronny; Meinl, Walter; Schneider, Heiko; Batke, Monika; Frank, Heinz; Seidel, Albrecht; Glatt, Hansruedi Biochemical Pharmacology, 2008 , vol. 75, # 2 p. 527 - 537

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Citation Number: 11

Abstract

Alkylated polycyclic aromatic hydrocarbons can be metabolically activated via benzylic hydroxylation and sulphation to electrophilically reactive esters. However, we previously found that the predominant biotransformation route for the hepatocarcinogen 1- hydroxymethylpyrene (1-HMP) in the rat in vivo is the oxidation of the side chain by alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases to the carboxylic acid. Inhibition ...