Alumina promoted cyclization of α-nitro-oximes: a new entry to the synthesis of 1, 2, 5-oxadiazoles N-oxides (furoxans)

M Curini, F Epifano, MC Marcotullio, O Rosati…

Index: Curini, Massimo; Epifano, Francesco; Marcotullio, Maria Carla; Rosati, Ornelio; Ballini, Roberto; Bosica, Giovanna Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8817 - 8820

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Citation Number: 29

Abstract

Only few years ago furoxan derivatives were found to play an important pharmacological role, as they are able to increase the cytosolic level of cGMP in human platelets, 1 to activate the rat liver soluble guanylate cyclase and to release NO when treated with thiol compounds under physiological conditions 2 resulting in a potent vasodilating effect. 3 Very recently it has also been discovered that furoxan derivatives exert anti-HIV1, antitrypanosomal and ...