Imine-Directed metalation of o-tolualdehyde: the use of catalytic amine base. A route to 2-(8-phenyloctyl) benzaldehyde

…, MB Mitchell, SAC Smith, K Gombatz…

Index: Forth, Michael A.; Mitchell, Michael B.; Smith, Stephen A. C.; Gombatz, Kerry; Snyder, Lawrence Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2616 - 2619

Full Text: HTML

Citation Number: 13

Abstract

Much effort has been expended in the search for leukotriene antagonists in response to indications that leukotrienes are mediators in the biochemical sequence of events which give rise to asthma.'Intensive studies into the design and synthesis of potential antagonists has identified a series of [(phenyloctyl) phenyl] propionic acids that act as high affinity peptidoleukotriene antagonists. One of these, discovered within SmithKline Beecham, is ...