Chemistry of carbanions. XXIII. Use of metal complexes to control the aldol condensation

HO House, DS Crumrine, AY Teranishi…

Index: House,H.O. et al. Journal of the American Chemical Society, 1973 , vol. 95, p. 3310 - 3324

Full Text: HTML

Citation Number: 382

Abstract

Abstract: Preformed lithium enolates may be used as reactants in aldol condensation with other carbonyl compounds provided reaction conditions are chosen that intercept the initially formed aldol products as metal chelates 9. Although lithium may serve as the chelating metal cation in nonpolar solvents at low temperatures, it is experimentally more convenient to add a divalefit metal salt such as anhydrous MgBrz, or especially ZnClz. By adding an ...