3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction: Extension to Selenium Derivatives

D Fajkusova, P Pazdera

Index: Fajkusova, Dagmar; Pazdera, Pavel Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 7 p. 1683 - 1689

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Abstract

A thiazole derivative can be easily prepared, eg, from an α-thiocyanatoketone and a nitrogen nucleophile. In this work, α-bromopropiophenone was chosen as a starting compound. Since the carbonyl group facilitates nucleophilic substitution, bromine can be simply replaced with the thiocyanato group. The following reaction with hydroxylamine hydrochloride provides an intermediate, which undergoes a ring closure reaction. Finally, ...