Thiocarbamate Derivatives of 2-Methyl-2-propyl-1, 3-propanediol1

BJ Ludwig, FJ Stiefel, LS Powell…

Index: Ludwig,B.J. et al. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 174 - 177

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Citation Number: 4

Abstract

Attempts to obtain VII via the bis (isothiouronium) salt by the reaction of TTa with thiourea were unproductive. KO reaction took place when the reactants were refluxed in 2-propanol for 21 hr. When the reaction was attempted at 1.50'in dimethylformamide or propylene glycol, thiourea apparently underwent isomerization to ammonium thiocyanate6 at a rate greater than it reacted with T'a, since ammonium tosylate was the only product which ...