Three leflunomide metabolite analogs

S Ghosh, JD Jennissen, Y Zheng…

Index: Ghosh, Sutapa; Jennissen, Jason D.; Zheng, Yaguo; Uckun, Fatih M. Acta Crystallographica, Section C: Crystal Structure Communications, 2000 , vol. 56, # 10 p. 1254 - 1257

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Citation Number: 9

Abstract

The title compounds, 1-cyano-2-hydroxy-N-[4-(methylsulfonyl) phenyl] but-2-enamide, C12H12N2O4S, PHI492, 1-cyano-2-hydroxy-N-[3-(methylsulfonyl) phenyl] but-2-enamide, C12H12N2O4S, PHI493, and N-[3-bromo-4-(trifluoromethoxy) phenyl]-1-cyano-2- hydroxybut-2-enamide, C12H8BrF3N2O3, PHI495, are potent inhibitors of Bruton's tyrosine kinase (BTK). The molecular structures of these compounds are similar and they display ...