Design and synthesis of new 1, 4-dihydropyridines containing 4 (5)-chloro-5 (4)-imidazolyl substituent as a novel calcium channel blocker

…, A Davood, AR Nematollahi, AR Dehpoor…

Index: Iman, Maryam; Davood, Asghar; Nematollahi, Ali Reza; Dehpoor, Ahmad Rerza; Shafiee, Abbas Archives of Pharmacal Research, 2011 , vol. 34, # 9 p. 1417 - 1426

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Citation Number: 15

Abstract

Abstract New analogues of nifedipine, in which the ortho-nitro phenyl group at position 4 has been replaced by 4 (5)-chloro-5 (4)-imidazolyl substituent and which are able to interact with the receptor by hydrogen binding were designed, synthesized, and evaluated as calcium channel antagonists. The designed dihydropyridines were synthesized using the Hantzsch condensation and evaluated as calcium channel antagonists using the high K+ ...