Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication

…, M Iqbal, J Bentley, SA Allman, G Edwards…

Index: Stachulski, Andrew V.; Pidathala, Chandrakala; Row, Eleanor C.; Sharma, Raman; Berry, Neil G.; Lawrenson, Alexandre S.; Moores, Shelley L.; Iqbal, Mazhar; Bentley, Joanne; Allman, Sarah A.; Edwards, Geoffrey; Helm, Alison; Hellier, Jennifer; Korba, Brent E.; Semple, J. Edward; Rossignol, Jean-Francois Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8670 - 8680

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Citation Number: 16

Abstract

We report the activities of a number of thiazolides [2-hydroxyaroyl-N-(thiazol-2-yl) amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure– activity relationships (SARs) of thiazolides against HCV are less predictable than against hepatitis B virus (HBV), though an electron-withdrawing group at C (5′) generally correlates with potency. Among the related salicyloylanilides, the m-fluorophenyl ...