Chirality

Lack of Enantioselectivity in the SULT1A3-catalyzed Sulfoconjugation of Normetanephrine Enantiomers: An In Vitro and Computational Study

E Grouzmann, JB Gualtierotti, S Gerber-Lemaire…

Index: Grouzmann, Eric; Gualtierotti, Jean-Baptiste; Gerber-Lemaire, Sandrine; Abid, Karim; Brakch, Noureddine; Pedretti, Alessandro; Testa, Bernard; Vistoli, Giulio Chirality, 2013 , vol. 25, # 1 p. 28 - 34

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Abstract

ABSTRACT (1R)-Normetanephrine is the natural stereoisomeric substrate for sulfotransferase 1A3 (SULT1A3)-catalyzed sulfonation. Nothing appears known on the enantioselectivity of the reaction despite its potential significance in the metabolism of adrenergic amines and in clinical biochemistry. We confronted the kinetic parameters of the sulfoconjugation of synthetic (1R)-normetanephrine and (1S)-normetanephrine by ...