A Novel Synthetic Route for the Anti??HIV Drug MC??1220 and its Analogues

…, R Loddo, G Collu, P La Colla, EB Pedersen

Index: Loksha, Yasser M.; Globisch, Daniel; Loddo, Roberta; Collu, Gabriella; La Colla, Paolo; Pedersen, Erik B. ChemMedChem, 2010 , vol. 5, # 11 p. 1847 - 1849

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Citation Number: 6

Abstract

The human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The viral reverse transcriptase (RT) of HIV-1 is one of the most promising targets for inhibition of HIV-1 replication; it can be inhibited by two classes of drugs that belong either to the nucleoside reverse transcriptase inhibitors (NRTIs) or to the nonnucleoside reverse transcriptase inhibitors (NNRTIs).[1–6] The HIV pandemic ...