Nucleosides. LXV. Synthesis of New Pteridine–N8–Nucleosides

…, B Waldscheck, W Pfleiderer

Index: Matysiak, Stefan; Waldscheck, Bernhard; Pfleiderer, Wolfgang Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 51 - 66

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Citation Number: 8

Abstract

A general synthetic approach to various isoxanthopterin??nucleosides starting from 6??methyl?? 2??methylthio??4 (3H), 7 (8H)??pterdinedione (1) has been developed. Ribosylation with 1??O?? acetyl??2, 3, 5??tri??O??benzoyl?螃漫?d??ribofuranose via the silyl??method led to 2 and reaction with 1??chloro??2??deoxy??3, 5??di??O??p??toluoyl?螃窿?d??ribofuranose using the DBU??method afforded 28. Protection of the amide function at O4 by benzylation to 5 and by a Mitsunobu ...