Bioorganic & medicinal chemistry

Synthesis of β-(S-methyl) thioaspartic acid and derivatives

J Heredia-Moya, KL Kirk

Index: Heredia-Moya, Jorge; Kirk, Kenneth L. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5908 - 5913

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Abstract

β-(S-Methyl) thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes. Critical to research designed to determine the biological function of β-(S-methyl) thioaspartic acid will be the availability of synthetic β-(S-methyl) thioaspartic acid as well as derivatives designed for peptide ...