A General and Selective Copper??Catalyzed Cross??Coupling of Tertiary Grignard Reagents with Azacyclic Electrophiles

L Hintermann, L Xiao, A Labonne

Index: Hintermann, Lukas; Xiao, Li; Labonne, Aurelie Angewandte Chemie - International Edition, 2008 , vol. 47, # 43 p. 8246 - 8250

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Citation Number: 56

Abstract

Catalytic cross-coupling reactions continue to revolutionize the way of constructing CÀC bonds, particularly for olefinic, aromatic, and heteroaromatic compounds.[1] The cross- coupling reactions of C (sp3)-centered substrates bearing βhydrogen atoms remains challenging because of the competing β-hydride elimination and isomerization [2] of the catalystbound alkyl groups.[3] The catalytic cross-coupling of sterically hindered tertiary ...