Nucleosides, Nucleotides and Nucleic Acids

Synthesis and anti-hepatitis C virus activity of 2′(β)-hydroxyethyl and 4′(α)-hydroxymethyl carbodine analogues

LJ Liu, JH Hong

Index: Liu, Lian Jin; Hong, Joon Hee Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 11-12 p. 1007 - 1015

Full Text: HTML

Citation Number: 4

Abstract

2′(β)-Hydroxyethylated adenosine is a potent and selective inhibitor of hepatitis C virus (HCV) replication targeting the RNA-dependent RNA polymerase of HCV, NS5B. The synthesis and anti-HCV evaluation of carbodine analogues are described. The cyclopentene intermediate 10 was successfully made via sequential Johnson-Claisen orthoester rearrangement and ring-closing metathesis. Coupling of bases via a Pd (0) ...