Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid
A Ammazzalorso, R Amoroso, G Bettoni, M Fantacuzzi…
Index: Ammazzalorso, Alessandra; Amoroso, Rosa; Bettoni, Giancarlo; Fantacuzzi, Marialuigia; De Filippis, Barbara; Giampietro, Letizia; Maccallini, Cristina; Paludi, Domenico; Tricca, Maria L. Farmaco, 2004 , vol. 59, # 9 p. 685 - 690
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Citation Number: 9
Abstract
Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin-and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.