The Journal of Organic Chemistry

One-pot reductive amination of conjugated aldehydes and ketones with silica gel and zinc borohydride

BC Ranu, A Majee, A Sarkar

Index: Ranu, Brindaban C.; Majee, Adinath; Sarkar, Arunkanti Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 370 - 373

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Citation Number: 136

Abstract

Reductive amination, which allows the conversion of carbonyl functionality to an amine, is an important process in organic synthesis. The reaction involves the initial formation of an imine from the reaction of a carbonyl compound with an amine and its subsequent reduction to an alkylated amine. The reductive amination reaction is termed as direct when a mixture of the carbonyl compound and the amine is treated with proper reducing agent in a single ...