3-substituted thiophenes. VII. Derivatives of 3-aminothiophene

E Campaigne, PA Monroe

Index: Campaigne; Monroe Journal of the American Chemical Society, 1954 , vol. 76, p. 2447,2449

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Citation Number: 29

Abstract

The syntheses of N-substituted 3-aminothiophenes have been investigated. These were prepared by the application of the Hofmann hypobromite rearrangement procedure to 3- thenamide, followed by reaction with the appropriate acid chloride or anhydride. It is significant that 2-thenamide fails to undergo the Hofmann rearrangement while 3-thenamide gives high yields of the corresponding amine under the conditions used. Several N- ...