Synthesis and biological evaluation of thiobenzanilides as anticancer agents

…, YK Chen, CC Liao, LS Chang, JJ Wang

Index: Hu, Wan-Ping; Yu, Hsin-Su; Chen, Yan-Ren; Tsai, Yi-Min; Chen, Yin-Kai; Liao, Chao-Cheng; Chang, Long-Sen; Wang, Jeh-Jeng Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5295 - 5302

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Citation Number: 34

Abstract

A series of novel thiobenzanilides is described. These compounds have been previously found to show strong biological activity such as antimycotic and antifungal actions. This is the first demonstration on the mechanism of the anticancer effect of thiobenzanilide agents (4a–c) on human melanoma A375 cells. The cytotoxic studies of compounds 4a–c on human melanoma A375 cells indicate thiobenzanilides induced higher cytotoxicity than ...