Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells
T Muller, L Grandbarbe, E Morga, P Heuschling…
Index: Muller, Thierry; Grandbarbe, Luc; Morga, Eleonora; Heuschling, Paul; Luu, Bang Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6023 - 6026
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Citation Number: 14
Abstract
The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12- hydroxy-dodecyl)-2, 5, 7, 8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain (n= 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-α (TNF-α) by lipopolysaccharide (LPS)-activated microglia.
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