Enantioselective Aza??Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts, Usage of Multiple …

…, C Margarita, A Vecchioni, I Bordacchini…

Index: Silvi, Mattia; Renzi, Polyssena; Rosato, Deborah; Margarita, Cristiana; Vecchioni, Alessio; Bordacchini, Ivan; Morra, Diego; Nicolosi, Alessandro; Cari, Riccardo; Sciubba, Fabio; Scarpino Schietroma, Daniele M.; Bella, Marco Chemistry - A European Journal, 2013 , vol. 19, # 30 p. 9973 - 9978

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Citation Number: 7

Abstract

Abstract A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.