Tetrahedron letters

TiCl 4/Bu 3 N/(catalytic TMSOTf): Efficient agent for direct aldol addition and Claisen condensation

Y Yoshida, R Hayashi, H Sumihara, Y Tanabe

Index: Yoshida, Yoshihiro; Hayashi, Ryosuke; Sumihara, Hiromasa; Tanabe, Yoo Tetrahedron Letters, 1997 , vol. 38, # 50 p. 8727 - 8730

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Citation Number: 69

Abstract

TiCl4/Bu3N conducts highly efficient cross aldol additions between different ketones and between ketones and aldehydes, in good to excellent yields with high syn- stereoselectivities. As an extension, direct Claisen condensation between methyl esters was also promoted by TiCl4/Bu3N with 0.05 equiv of TMSOTf co-catalyst.