Potential organ??or tumor??imaging agents XIX: Radioiodinated antiarrhythmic drugs as potential myocardial imaging agents

…, BR Lucchesi, VV Ranade, M Mimnaugh…

Index: Korn; Gibson; Kniffen; Lucchesi; Ranade; Mimnaugh; Yu; Counsell Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 9 p. 1010 - 1013

Full Text: HTML

Citation Number: 4

Abstract

Abstract Iodinated and radioiodinated analogs of propranolol and N, N-dimethylpropranolol were synthesized wherein an iodophenyl moiety replaced the naphthalene ring of the parent drug. These new compounds were evaluated not only for their β-adrenergic blocking and antiarrhythmic activities but also for their ability to accumulate selectively in myocardial tissue. Like propranolol, the iodinated analogs displayed comparable β-blocking and ...